Vallancien G, Beurton D, Szemat R, Raust J V, Gonties D, Gubler M C, Habib R, Cukier J
J Urol (Paris). 1982;88(1):27-30.
The authors sought to determine what links existed between foetal vesico-ureteric reflux and renal dysplasia. Using sheep with operation upon the foetuses in utero, at a fairly early stage of gestation, the following were obtained: 1) Foetal vesico-ureteric reflux by unilateral excision of a ureteric meatus. 2) Stenosis of the foetal ureter by ligation. In the first case, no renal dysplasia occurred. In the second case, dysplasia-type parenchymatous lesions were found. This led them to conclude that the direct relationship between isolated foetal vesico ureteric reflux created experimentally in a normal ureter (without any additional functional or organic obstructive factor) and renal dysplasia could not be demonstrated in the sheep foetus.
作者试图确定胎儿膀胱输尿管反流与肾发育不良之间存在何种联系。通过在妊娠相当早期对子宫内的胎儿进行手术的绵羊，获得了以下结果：1）通过单侧切除输尿管口造成胎儿膀胱输尿管反流。2）通过结扎造成胎儿输尿管狭窄。在第一种情况下，未发生肾发育不良。在第二种情况下，发现了发育异常型实质病变。这使他们得出结论，在绵羊胎儿中，无法证明在正常输尿管中实验性产生的孤立胎儿膀胱输尿管反流（无任何额外的功能性或器质性阻塞因素）与肾发育不良之间存在直接关系。
