Bennett W M, Parker R A, Elliott W C, Gilbert D N, Houghton D C
J Infect Dis. 1982 Mar;145(3):370-3. doi: 10.1093/infdis/145.3.370.
Age-matched male and female Fischer 344 rats were treated with gentamicin, 40 mg/kg of animal body weight per day, for three to 21 days. Renal dysfunction was less severe in females as measured by concentrations of blood urea nitrogen and creatinine and by cortical slice uptake of p-aminohippuric acid and N1-methylnicotinamide chloride. Also, cortical concentrations of gentamicin in females were lower than in males. Neither exogenous testosterone administered to adult females nor castration of prepubertal males changed the pattern of dysfunction. These results show that sex affects susceptibility to aminoglycoside nephrotoxicity by mechanisms that are undefined but that are apparently unrelated to testosterone. The variable of sex needs to be considered in interpreting the results of studies of experimental aminoglycoside nephrotoxicity.
将年龄匹配的雄性和雌性Fischer 344大鼠用庆大霉素治疗，每天每千克动物体重40毫克，持续三至二十一天。通过血尿素氮和肌酐的浓度以及对氨基马尿酸和氯化N1-甲基烟酰胺的皮质切片摄取量来衡量，雌性大鼠的肾功能障碍较轻。此外，雌性大鼠皮质中庆大霉素的浓度低于雄性。对成年雌性大鼠施用外源性睾酮或对青春期前雄性大鼠进行阉割均未改变功能障碍的模式。这些结果表明，性别通过尚未明确但显然与睾酮无关的机制影响对氨基糖苷类肾毒性的易感性。在解释实验性氨基糖苷类肾毒性研究结果时需要考虑性别的变量。
