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Effect of carboxylic acids on permeation of chlorpromazine through dimethyl polysiloxane membrane.

作者信息

Gasco M R, Trotta M, Carlotti M E

出版信息

J Pharm Sci. 1982 Feb;71(2):239-41. doi: 10.1002/jps.2600710224.

DOI:10.1002/jps.2600710224
PMID:7062253
Abstract

The effect of carboxylic acids on the permeation of chlorpromazine was investigated through a dimethyl polysiloxane nonpolar membrane. The permeability of the diffusate, at pH 5.8, increases considerably in the presence of carboxylic acids or phosphate, probably due to an ion-pair formation between the relative anions and chlorpromazine.

摘要

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