Nakano M, Juni K, Arita T
J Pharm Sci. 1976 May;65(5):709-12. doi: 10.1002/jps.2600650520.
The effects of caffeine, beta-cyclodextrin, and povidone on the permeation behavior of butamben from saturated solutions in these complexing agents through a dimethyl polysiloxane membrane were investigated at 30 degrees. In all systems, these agents increased the rate of release over the plain saturated drug solution. The effect was more pronounced with caffeine and beta-cyclodextrin than with povidone. Interpretation of these results with the aid of solubility data for the corresponding systems led to the following generalization. For a fixed total (free and complexed) amount of drug available for release, sustained release is associated with systems containing more stable complexes. The practical value of this approach to the controlled release of drug is discussed.
在30摄氏度下，研究了咖啡因、β-环糊精和聚维酮对布他米酯在这些络合剂的饱和溶液中透过二甲基聚硅氧烷膜的渗透行为的影响。在所有体系中，这些试剂都提高了药物从普通饱和溶液中的释放速率。咖啡因和β-环糊精的效果比聚维酮更显著。借助相应体系的溶解度数据对这些结果进行解释，得出了以下普遍结论。对于可供释放的固定总量（游离和络合）药物，缓释与含有更稳定络合物的体系相关。讨论了这种药物控释方法的实际价值。
