Kolbusz W E, Lee C, Grayhack J T
J Urol. 1982 Mar;127(3):581-4. doi: 10.1016/s0022-5347(17)53916-6.
Although prolactin has a synergistic effect with testosterone in stimulating growth of the lateral lobe of the rat prostate, the role of prolactin in the absence of testosterone has not been well established. We studied the effect of prolactin on the rate of prostatic regression induced by castration in mature Sprague-Dawley rats. Anterior pituitaries from female rats were transplanted under the renal capsule in all rats. Castration and unilateral nephrectomy were carried out 1 week later. Half of the animals had the normal, non-grafted kidney removed and another half had the kidney bearing the pituitary grafts excised. Rats were sacrificed on days 0, 7, 10 and 14 and 3 lobes of the prostate were dissected separately. The lateral lobe showed a marked decrease in the rate of regression in the pituitary graft-bearing rats. In control animals, the relative weight of the lateral lobe on days 7, 10 and 14 was 38 +/- 2 per cent (mean +/- SE), 33 +/- 2 per cent and 26 +/- 2 per cent of the day 0 value, respectively; the respective relative weight in animals carrying pituitary grafts was 67 +/- 4 per cent, 51 +/- 5 per cent, and 38 +/- 3 per cent of the day 0 value. The difference in the weight of the lateral lobe between the 2 groups was significant on days 7 (p less than 0.001) and 10 (p less than 0.05) and was not significant on day 14. There was no difference in the mean body weight in graft bearing and non-graft bearing animals. Bilateral adrenalectomy at the time of castration did not influence the rate of prostatic regression in either group. Furthermore, pituitaries implanted in rats castrated for 3 weeks had no stimulatory effect of the prostates. These results indicate that increased endogenous prolactin, in the absence of testicular and adrenal secretion, delays the castration-induced regression of the lateral lobe of the prostate of Sprague-Dawley rats.
虽然催乳素在刺激大鼠前列腺侧叶生长方面与睾酮具有协同作用，但在缺乏睾酮的情况下催乳素的作用尚未完全明确。我们研究了催乳素对成熟斯普拉格 - 道利大鼠去势诱导的前列腺退化速率的影响。将雌性大鼠的垂体前叶移植到所有大鼠的肾包膜下。1周后进行去势和单侧肾切除术。一半动物切除正常的、未移植垂体的肾脏，另一半切除带有垂体移植的肾脏。在第0、7、10和14天处死大鼠，并分别解剖前列腺的3个叶。在带有垂体移植的大鼠中，侧叶的退化速率明显降低。在对照动物中，第7、10和14天侧叶的相对重量分别为第0天值的38±2%（平均值±标准误）、33±2%和26±2%；在带有垂体移植的动物中，相应的相对重量分别为第0天值的67±4%、51±5%和38±3%。两组之间侧叶重量的差异在第7天（p<0.001）和第10天（p<0.05）有统计学意义，在第14天无统计学意义。带有移植和未带移植的动物平均体重没有差异。去势时双侧肾上腺切除术对两组的前列腺退化速率均无影响。此外，植入去势3周大鼠体内的垂体对前列腺没有刺激作用。这些结果表明，在缺乏睾丸和肾上腺分泌的情况下，内源性催乳素增加会延迟斯普拉格 - 道利大鼠前列腺侧叶去势诱导的退化。
