Thomas C B, Duszynski K R, Shaffer J W
Johns Hopkins Med J. 1982 Mar;150(3):89-94.
In a study of the serum cholesterol of 30 male medical students who later developed major cancer, no consistent relationship between baseline cholesterol level and cancer was found during follow-up studies extending for up to 33 years. However, different cancer types seemed to have different cholesterol profiles: subjects who developed melanoma or lung cancer had relatively low initial levels, while subjects who developed cancer of the digestive system, brain or urinary bladder tended to have high initial values. Sequential cholesterol measurements made on two men with cancer of the colon are presented. It is suggested that such sequential cholesterol studies combined with knowledge of the types of cancers involved would help to clarify such complex interrelationships as may exist. The implications of a two-population hypothesis are discussed.
在一项针对30名后来患上重大癌症的男性医科学生的血清胆固醇研究中，在长达33年的随访研究期间，未发现基线胆固醇水平与癌症之间存在一致的关系。然而，不同类型的癌症似乎具有不同的胆固醇特征：患黑色素瘤或肺癌的受试者初始水平相对较低，而患消化系统、脑或膀胱癌的受试者往往具有较高的初始值。文中给出了对两名结肠癌患者进行的连续胆固醇测量结果。研究表明，这种连续胆固醇研究结合所涉及癌症类型的知识，将有助于阐明可能存在的此类复杂的相互关系。文中还讨论了双总体假设的意义。
