Isles C G, Hole D J, Gillis C R, Hawthorne V M, Lever A F
MRC Blood Pressure Unit, Western Infirmary, Glasgow.
BMJ. 1989 Apr 8;298(6678):920-4. doi: 10.1136/bmj.298.6678.920.
The relation between plasma cholesterol concentration and mortality from coronary heart disease, incidence of and mortality from cancer, and all cause mortality was studied in a general population aged 45-64 living in the west of Scotland. Seven thousand men (yielding 653 deaths from coronary heart disease, 630 new cases of cancer, and 463 deaths from cancer) and 8262 women (322 deaths from coronary heart disease, 554 new cases of cancer, and 395 deaths from cancer) were examined initially in 1972-6 and followed up for an average of 12 years. All cause mortality was not related to plasma cholesterol concentration. This was largely a consequence of a positive relation between cholesterol values and mortality from coronary heart disease being balanced by inverse relations between cholesterol and cancer and between cholesterol and other causes of death. These changes were highly significant for coronary heart disease and cancer in men and significant for coronary heart disease and other causes of death in women. The inverse association between cholesterol concentration and cancer in men was strongest for lung cancer, was not merely a function of the age at which a subject died, was present for the incidence of cancer as well as mortality from cancer, and persisted when new cases or deaths occurring within the first four years of follow up were excluded from the analysis.
对居住在苏格兰西部的45至64岁普通人群，研究了血浆胆固醇浓度与冠心病死亡率、癌症发病率及死亡率以及全因死亡率之间的关系。1972年至1976年对7000名男性（其中653人死于冠心病，630人患新发癌症，463人死于癌症）和8262名女性（322人死于冠心病，554人患新发癌症，395人死于癌症）进行了初始检查，并平均随访了12年。全因死亡率与血浆胆固醇浓度无关。这主要是由于胆固醇水平与冠心病死亡率之间的正相关关系，被胆固醇与癌症以及胆固醇与其他死因之间的负相关关系所平衡。这些变化在男性的冠心病和癌症方面具有高度显著性，在女性的冠心病和其他死因方面具有显著性。男性中胆固醇浓度与癌症之间的负相关在肺癌方面最为明显，不仅仅是受试者死亡年龄的函数，在癌症发病率和死亡率方面均存在，并且在分析中排除随访前四年内发生的新病例或死亡后仍然存在。
