Safrazbekian R R, Sukasian R S, Arzanunts E M
Vopr Med Khim. 1978 Sep-Oct;24(5):640-5.
Effects of hydrazide and isopropyl hydrazide of beta-/2-methyl indolyl-3/propionic acid as well as dihydrazide and isopropyl dihydrazide of alpha-butyl-beta/2-methyl-5-carboxyindolyl-3/propionic acid on activity of monoamine oxidase from rat brain were studied in vivo and in vitro. The effects of the preparations depend on the initial activity of the enzyme, concentrations of the compounds and on the substrate used. Decreased monoamine oxidase activity was the most suitable condition for detection of activating effect of compounds studied.
研究了β-（2-甲基吲哚基-3）丙酸酰肼和异丙基酰肼以及α-丁基-β-（2-甲基-5-羧基吲哚基-3）丙酸二酰肼和异丙基二酰肼对大鼠脑单胺氧化酶活性的体内和体外作用。这些制剂的作用取决于酶的初始活性、化合物的浓度以及所使用的底物。单胺氧化酶活性降低是检测所研究化合物激活作用的最适宜条件。
