Strel'tsova V N, Pavlenko-Mikhaĭlov Iu N
Vopr Onkol. 1978;24(9):25-30.
In experiments on 465 male and female white non-lineal rats irradiated in their embryonal (7th day--240 rats), organogenesis (14th day--105 rats) and foetal periods of embryogenesis (19th day--120 rats) with 60Co--rays in a dose of 100 r, its actual power 168 r/m, and on 73 control rats the authors have studied the frequency and terms of tumors appearance. A group comprising 219 experimental rats and 53 control animals, died during a period of 200--600 days following their birth, was analysed. Irradiation at different stages of embryogenesis would provide a statistically significant increase in the frequency of tumors and shorten the terms of their appearance. In control animals tumors arose in 16,9% (in 9 of 53 animals). Embryonal and foetal periods of embryogenesis proved to be mostly susceptible as evidenced by the yield of radiation tumors. In animals exposed to irradiation in their embryonal period tumors arose in 64,5% (in 69 of 107 rats), in the foetal period--in 62,8% (in 44 of 70 rats), and during the period of organogenesis--in 42,8% (in 18 of 42 rats). Rats exposed to irradiation in the embryonal and foetal period of embryogenesis developed tumors to the 120--180th day of the experiment, while in the organogenesis period--to the 400th day. Maximum tumor appearance was observed in the last third of the lifetime. Male rats irradiated in the period of embryogenesis developed tumors of the mammary gland and bones, females- ovarian and bone tumors, which were absent in control animals.
在对465只雄性和雌性白色非品系大鼠进行的实验中，作者用剂量为100伦琴、实际功率为168伦琴/分钟的60Co射线，在胚胎期（第7天，240只大鼠）、器官形成期（第14天，105只大鼠）和胚胎发育的胎儿期（第19天，120只大鼠）对其进行照射，并以73只对照大鼠作为对照，研究了肿瘤出现的频率和时间。分析了一组包括219只实验大鼠和53只对照动物的样本，这些动物在出生后的200 - 600天内死亡。在胚胎发育的不同阶段进行照射会使肿瘤出现的频率在统计学上显著增加，并缩短肿瘤出现的时间。在对照动物中，肿瘤发生率为16.9%（53只动物中有9只）。胚胎发育的胚胎期和胎儿期被证明对辐射肿瘤的发生最为敏感。在胚胎期接受照射的动物中，肿瘤发生率为64.5%（107只大鼠中有69只），在胎儿期为62.8%（70只大鼠中有44只），在器官形成期为42.8%（42只大鼠中有18只）。在胚胎发育的胚胎期和胎儿期接受照射的大鼠在实验的第120 - 180天出现肿瘤，而在器官形成期接受照射的大鼠在第400天出现肿瘤。在寿命的最后三分之一时间内观察到肿瘤出现的最大值。在胚胎期接受照射的雄性大鼠出现乳腺和骨骼肿瘤，雌性大鼠出现卵巢和骨骼肿瘤，而对照动物中未出现这些肿瘤。
