Zweifler A J, Julius S
N Engl J Med. 1982 Apr 15;306(15):890-4. doi: 10.1056/NEJM198204153061502.
Platelet catecholamine content was determined by radioenzymatic assay in 16 patients with elevated plasma norepinephrine or epinephrine or both and a clinical picture suggesting pheochromocytoma. Twenty-two normal subjects served as controls. Pheochromocytoma was documented in 10 patients, all of whom had markedly elevated platelet catecholamines. The other six patients had no tumor, and their platelet catecholamine levels were normal. Platelet catecholamines tended to return to normal more slowly than plasma catecholamines after removal of the pheochromocytoma, suggesting that platelets were rich in stored catecholamines. Determination of platelet catecholamine content is a helpful aid to the diagnosis of pheochromocytoma in patients with suggestive but not diagnostic elevations of the plasma catecholamine concentration.
采用放射酶分析法测定了16例血浆去甲肾上腺素或肾上腺素或两者均升高且临床表现提示嗜铬细胞瘤患者的血小板儿茶酚胺含量。22名正常受试者作为对照。10例患者确诊为嗜铬细胞瘤，所有患者的血小板儿茶酚胺均显著升高。另外6例患者无肿瘤，其血小板儿茶酚胺水平正常。切除嗜铬细胞瘤后，血小板儿茶酚胺恢复正常的速度往往比血浆儿茶酚胺慢，提示血小板富含储存的儿茶酚胺。对于血浆儿茶酚胺浓度有提示性但未确诊升高的患者，测定血小板儿茶酚胺含量有助于嗜铬细胞瘤的诊断。
