Blättler W, Mühlemann M
Schweiz Med Wochenschr. 1982 Jan 23;112(4):115-7.
An angiologist's experience with the symptom of restless legs is reported. The condition was diagnosed in 103 patients presenting with pain in their legs occurring predominantly at rest and vanishing with walking. Organic lesions could not be identified (in 76%) or were not responsible for the discomfort (in 24%). A depressive state, most often masked, was recognized in 67%. In 42% anxiety was present alone, and in 49% frank depression was diagnosed. In 9% psychiatric treatment was mandatory. Patients with no depression were either not treated (33%) or were given type I-antiarrhythmic drugs (mostly disopyramide) with good results. These drugs were only transiently effective in depressed patients since anxiety was often intensified when the symptom of restless legs disappeared. Antidepressant agents, though ineffective when given alone, were most helpful when administered together with disopyramide.
报告了一位血管病学家对不宁腿综合征的诊治经验。103例以腿部疼痛为主诉的患者被诊断为此病，疼痛主要在休息时出现，行走时消失。76%的患者未发现器质性病变，24%的患者不适与器质性病变无关。67%的患者存在抑郁状态，多数为隐匿性。42%的患者仅有焦虑，49%的患者被诊断为明显抑郁。9%的患者需要进行精神科治疗。无抑郁的患者要么未接受治疗（33%），要么给予I类抗心律失常药物（主要是丙吡胺），效果良好。这些药物对抑郁患者只是暂时有效，因为不宁腿症状消失时焦虑常常加重。抗抑郁药单独使用无效，但与丙吡胺联合使用时最有帮助。
