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喹啉,一种转录后掺入真核生物转运RNA的修饰碱基:在自然界中广泛分布。

Queuine, a modified base incorporated posttranscriptionally into eukaryotic transfer RNA: wide distribution in nature.

作者信息

Katze J R, Basile B, McCloskey J A

出版信息

Science. 1982 Apr 2;216(4541):55-6. doi: 10.1126/science.7063869.

DOI:10.1126/science.7063869
PMID:7063869
Abstract

Queuine, a modified base found in transfer RNA, appears to be a new dietary factor because (i) previous studies have shown that mice require it for the expression of queuine-containing transfer RNA's but apparently do not synthesize it, and (ii) significant amounts of free queuine are present in common plant and animal food products.

摘要

喹啉是转运核糖核酸中发现的一种修饰碱基,它似乎是一种新的膳食因子,原因如下:(i)先前的研究表明,小鼠表达含喹啉的转运核糖核酸需要它,但显然无法合成它;(ii)常见的动植物食品中存在大量游离喹啉。

相似文献

1
Queuine, a modified base incorporated posttranscriptionally into eukaryotic transfer RNA: wide distribution in nature.喹啉,一种转录后掺入真核生物转运RNA的修饰碱基:在自然界中广泛分布。
Science. 1982 Apr 2;216(4541):55-6. doi: 10.1126/science.7063869.
2
The absence of the diet-derived 7-deazapurine, queuine in artificial liquid diets.
JPEN J Parenter Enteral Nutr. 1989 Sep-Oct;13(5):542-4. doi: 10.1177/0148607189013005542.
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Salvage of the nucleic acid base queuine from queuine-containing TRNA by animal cells.动物细胞从含喹啉的转运核糖核酸中挽救核酸碱基喹啉。
Biochem Biophys Res Commun. 1982 Nov 16;109(1):159-67. doi: 10.1016/0006-291x(82)91579-0.
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Queuine metabolism and cadmium toxicity in Drosophila melanogaster.黑腹果蝇中的喹啉代谢与镉毒性
Biofactors. 1991 Jan;3(1):41-7.
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Administration of exogenous queuine is essential for the biosynthesis of the queuosine-containing transfer RNAs in the mouse.外源性 queuine 的给药对于小鼠中含 queuosine 的转运 RNA 的生物合成至关重要。
J Biol Chem. 1981 Nov 25;256(22):11591-4.
6
Presence of queuine in Drosophila melanogaster: correlation of free pool with queuosine content of tRNA and effect of mutations in pteridine metabolism.黑腹果蝇中喹啉的存在:游离库与tRNA中喹喔啉含量的相关性以及蝶啶代谢突变的影响。
Nucleic Acids Res. 1981 May 25;9(10):2351-66. doi: 10.1093/nar/9.10.2351.
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The nutrient factor queuine: biosynthesis, occurrence in transfer RNA and function.营养因子queuine:生物合成、在转运RNA中的存在及功能
Biofactors. 1988 Jan;1(1):27-9.
8
Defective transfer RNA-queuine modification in C3H10T1/2 murine fibroblasts transfected with oncogenic ras.用致癌性Ras转染的C3H10T1/2小鼠成纤维细胞中存在缺陷的转运RNA-反密码子第1位修饰。
Cancer Res. 1996 Feb 1;56(3):594-8.
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Evidence that the nucleic acid base queuine is incorporated intact into tRNA by animal cells.有证据表明,核酸碱基queuine被动物细胞完整地掺入到tRNA中。
Biochemistry. 1984 Mar 13;23(6):1171-6. doi: 10.1021/bi00301a022.
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Possible involvement of queuine in oxidative metabolism.
Biofactors. 1988 Oct;1(3):241-4.

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