Mathematical evaluation of the effects of tizolemide, furosemide and placebo in healthy adults.

The effects of single oral doses of tizolemide 100 mg, furosemide 80 mg and placebo on outputs of various electrolytes and metabolites in urine, on their corresponding urinary flows and on several blood solute concentrations were compared in 16 healthy volunteers. Tizolemide and furosemide exhibited similar quantitative effects on urinary and blood variables for 24 hours after administration but had different time-courses of renal excretion. Furosemide acted abruptly as loop diuretics do; tizolemide had more physiological time-courses, as shown by most diuretics whose main site of renal action lies at the cortical diluting segment.