Bennett J M, Kleynhans P H, Meyer J M, Geyser P G
S Afr Med J. 1982 Apr 3;61(14):524-6.
Restoration of blood flow in an occluded right coronary artery of a patient with an acute myocardial infarction was achieved with intracoronary administration of streptokinase. Patency of the vessel was restored within 15 minutes after starting the infusion. The dose of streptokinase used was 3000 U/min. The patient's pain was relieved and the raised ST segments returned to normal after patency was achieved. Cardiac output and stroke volume increased fro 3,6 to 6,3 1/min and from 61 to 70 ml respectively. No complications occurred during the infusion of streptokinase. Intracoronary thrombolysis might well establish itself as the treatment of choice for acute myocardial infarction in selected patients.
通过冠状动脉内注射链激酶,实现了一名急性心肌梗死患者闭塞的右冠状动脉血流的恢复。在开始输注后15分钟内血管恢复通畅。所用链激酶的剂量为3000 U/分钟。血管通畅后,患者的疼痛得到缓解,抬高的ST段恢复正常。心输出量和每搏输出量分别从3.6升/分钟增加到6.3升/分钟,从61毫升增加到70毫升。在输注链激酶期间未发生并发症。冠状动脉内溶栓很可能会成为特定患者急性心肌梗死的首选治疗方法。