Karp D D, Ervin T J, Tuttle S, Gorgone B C, Lavin P, Yunis E J
Vox Sang. 1982 Feb;42(2):57-61.
The use of granulocyte transfusions in profoundly neutropenic patients has increased markedly in recent years. Whenever a pulmonary infiltrate develops during the course of these transfusions, the question arises as to what role the transfusions are playing and whether the transfusions should be discontinued to prevent pulmonary deterioration. We have analyzed our recent experience of 593 granulocyte transfusions in 93 patients. 18 patients (19%) developed respiratory compromise or pulmonary infiltrates at some time during the course of granulocyte transfusion. 6 of the 18 cases were reactions to the granulocytes while the remainder were due to fluid overload or other causes. The risk of pulmonary complications did not correlate with the development of cytotoxic leukocyte antibodies, length of transfusion, or concomitant use of Amphotericin. They appeared to be more common in patients with active sepsis. Acute life-threatening pulmonary reactions were rare. Patients receiving granulocyte transfusions should be monitored carefully for pulmonary infiltrates, but other cases should be sought before the transfusions are discontinued.
近年来，粒细胞输注在严重中性粒细胞减少患者中的应用显著增加。在这些输注过程中，每当出现肺部浸润时，就会产生这样的问题：输注起到了什么作用，以及是否应该停止输注以防止肺部情况恶化。我们分析了近期对93例患者进行593次粒细胞输注的经验。18例患者（19%）在粒细胞输注过程中的某个时间出现了呼吸功能不全或肺部浸润。18例中的6例是对粒细胞的反应，其余则是由于液体超负荷或其他原因。肺部并发症的风险与细胞毒性白细胞抗体的产生、输注时间或两性霉素的同时使用无关。它们似乎在有活动性败血症的患者中更常见。急性危及生命的肺部反应很少见。接受粒细胞输注的患者应密切监测肺部浸润情况，但在停止输注之前应寻找其他病因。
