Shtok V N, Fedorova N V, Gadanova I V
Zh Nevropatol Psikhiatr Im S S Korsakova. 1982;82(1):60-6.
Clinical trials of pentoxiphylline (trental) used in the treatment of 164 patients were carried out. Of these patients, 32 were suffering from acute cerebral circulation disorders, 25 from chronic cerebrovascular insufficiency, 50 from cerebrovascular dystonia of various genesis, 12 from peripheral vasculopathy, and 5 from migraine. A favourable effect of pentoxiphylline on the course of the cerebrovascular disorders (except migraine) was noted. Rheographic examinations confirmed the improvement of the cerebral and peripheral circulation and revealed a two-phase effect of the drug on the vascular tone that manifested in alternations of periods of short-time moderate vasodilatation and vasoconstriction. Pentoxiphylline was also found to produce a venotonic effect. The pharmacodynamic mechanisms of the hemovascular effects of the drug are discussed. The optimal dose of pentoxyìphylline for a single intravenous injection is assumed to be 10 ml of solution containing 200 mg of the drug dissolved in physiological saline. The optimal dose for drop infusion is up to 15--20 ml of the same solution. In addition the drug is to be given orally in a dose of 400 mg (two dragees of 200 mg) two or three times a day. The treatment lasts 3 to 5 weeks.
对164例使用己酮可可碱（曲克芦丁）进行治疗的患者开展了临床试验。这些患者中，32例患有急性脑循环障碍，25例患有慢性脑血管供血不足，50例患有各种病因的脑血管张力障碍，12例患有周围血管病，5例患有偏头痛。已注意到己酮可可碱对脑血管疾病病程（偏头痛除外）有良好疗效。血流图检查证实脑循环和外周循环得到改善，并揭示了该药物对血管张力有两阶段效应，表现为短时间适度血管舒张期和血管收缩期交替出现。还发现己酮可可碱有静脉张力作用。讨论了该药物血管效应的药效学机制。单次静脉注射己酮可可碱的最佳剂量假定为10毫升含有200毫克药物且溶解于生理盐水中的溶液。滴注的最佳剂量为多达15至20毫升相同溶液。此外，该药物应以400毫克（两片200毫克糖衣片）的剂量口服，每日两到三次。治疗持续3至5周。
