Kuramitsu M, Matsui H, Tokuda M, Hatase O
Acta Med Okayama. 1982 Feb;36(1):1-10. doi: 10.18926/AMO/30708.
Two factors from normal rat liver cytoplasm inhibited the proliferation of cultured L-929 fibroblasts. One was arginase, the other was a small molecular weight inhibitor stable to trypsin and heat treatment. The small molecular weight inhibitor inhibited the protein and DNA synthesis of L-cells. Inhibition of DNA synthesis was thought to be secondary to the inhibition of protein synthesis.