Ohnoshi T, Oka A, Hayashi K, Ueoka H, Sato M, Nishihara R, Yasuoka M, Sando Y, Tanaka T, Kimura I
Acta Med Okayama. 1982 Feb;36(1):67-72. doi: 10.18926/AMO/30703.
Eighteen patients with advanced non-Hodgkin's lymphoma other than the diffuse histiocytic type were treated with a combination of adriamycin, vincristine, ifosfamide and prednisolone (AVIP). The objective response rate was 83% (15/18); 61% (11/18) achieved complete remission. The median duration of complete remission was 11 months ranging from 2 to 39+ months. Eleven of the 18 patients are still alive during the median follow-up time of 13 months. The median survival was 14+ months for complete responders, and 9.5 months for partial and nonresponders. A myelosuppressive toxicity was well tolerated. AVIP offers some hope as treatment of advanced non-Hodgkin's lymphoma.
