ACNU、阿霉素、甲氨蝶呤和泼尼松龙四联化疗方案治疗对VEPA（P）治疗难治的非霍奇金淋巴瘤患者的临床疗效
[Clinical efficacy of a quadruple combination chemotherapy with ACNU, adriamycin, methotrexate, and prednisolone for patients with non-Hodgkin's lymphoma, who were refractory to VEPA (P) treatment].
作者信息
Niitsu H, Fukuda M, Fukuda S, Takatsu H, Nakayama Y, Hirokawa M, Mamiya S, Miura I, Takahashi F, Yoshida K
出版信息
Gan To Kagaku Ryoho. 1984 Dec;11(12 Pt 1):2585-9.
A quadruple combination chemotherapy with ACNU, adriamycin, methotrexate and prednisolone (AAAP), was performed on 9 patients with non-Hodgkin's lymphoma, who had been previously treated with a VEPA (P) regimen. Complete remission rate was 44% (4/9) and, in four other patients, the tumor was decreased in size. Complete remission duration was from 30 days to over 390 days. Median survival time was 105 days. Myelosuppressive toxicity was severe. In eight patients, WBC counts were less than 3,000/mm3. In six patients, platelet counts were less than 100,000/mm3. An AAAP regimen is useful in relapse or for resistant forms of non-Hodgkin's lymphoma.
对9例曾接受过VEPA（P）方案治疗的非霍奇金淋巴瘤患者进行了ACNU、阿霉素、甲氨蝶呤和泼尼松龙（AAAP）四联化疗。完全缓解率为44%（4/9），另有4例患者肿瘤体积缩小。完全缓解持续时间为30天至超过390天。中位生存时间为105天。骨髓抑制毒性严重。8例患者白细胞计数低于3000/mm³。6例患者血小板计数低于100000/mm³。AAAP方案对非霍奇金淋巴瘤的复发或耐药形式有效。
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