Hammond M G, Sloan C S, Hall J L
Am J Obstet Gynecol. 1982 Feb 1;142(3):340-3. doi: 10.1016/0002-9378(82)90740-2.
Methods to evaluate male reproductive potential are limited. Conventional semen analysis does not necessarily reflect sperm functionality. In this study we investigated the correlation of the interspecies penetration test with clinical evaluation of 106 infertile couples. In vitro penetration results in 92 of 106 men correlated well with clinical diagnosis. In 28 couples with a male infertility factor, the mean penetration rate was 18%, whereas in 78 infertile couples with no known male factor, the rate was 50%. The mean for all patients tested was 40%. This was well below a mean of 73% for a donor population. The major discrepancy between the interspecies penetration test and clinical findings occurred in a group of nine patients with 0% penetration who had been judged normal by history and semen analysis. In general, the interspecies penetration test correlates well with male clinical evaluation but does the complementary information in certain cases. At present, its greatest utility seems to be in evaluation of unexplained infertility, in unexplained failure of female therapy, or in selection of patients for donor insemination.
评估男性生殖潜力的方法有限。传统的精液分析不一定能反映精子的功能。在本研究中，我们调查了异种穿透试验与106对不育夫妇临床评估之间的相关性。106名男性中有92人的体外穿透结果与临床诊断密切相关。在28对存在男性不育因素的夫妇中，平均穿透率为18%，而在78对无已知男性因素的不育夫妇中，该比率为50%。所有受试患者的平均穿透率为40%。这远低于供体人群73%的平均水平。异种穿透试验与临床结果之间的主要差异发生在一组9名患者中，他们的穿透率为0%，但根据病史和精液分析被判定为正常。总体而言，异种穿透试验与男性临床评估密切相关，但在某些情况下可提供补充信息。目前，其最大的用途似乎在于评估不明原因的不孕症、女性治疗的不明原因失败或供体授精患者的选择。
