Richardson B, Hohimer A R, Mueggler P, Bissonnette J
Am J Obstet Gynecol. 1982 Mar 15;142(6 Pt 1):678-83. doi: 10.1016/s0002-9378(16)32440-1.
Tracheal pressure and electrocortical activity were recorded in 10 unanesthetized fetal lambs in utero to determine the effect on fetal breathing movements (FBMs) of fasting and a subsequent infusion of glucose. The incidence of FBMs decreased significantly from 37.9% +/- 4.3% during fed control studies to 23.6% +/- 3.6% (P less than 0.05) after 24 to 36 hours of maternal fasting, with a related fall in fetal blood glucose. A 2-hour infusion of glucose to the fetuses of fasted animals resulted in a significant increase in FBMs to 39.5% +/- 4.9%, but only to a level similar to that in the fed control studies despite a twofold increase in the fetal concentration of glucose above fed control values. Changes in the incidence of FBMs paralleled the changes in fetal low-voltage electrocortical activity with alterations in glucose. In conclusion, FBM, although correlated with the concentration of glucose, may be influenced more by fetal hypoglycemia than hyperglycemia. Glucose appears to affect the incidence of FBM by altering the incidence of low-voltage electrocortical activity.
在10只未麻醉的子宫内胎羊身上记录气管压力和皮质电活动，以确定禁食及随后输注葡萄糖对胎儿呼吸运动（FBMs）的影响。在喂食对照研究期间，FBMs的发生率从37.9%±4.3%显著下降至母体禁食24至36小时后的23.6%±3.6%（P<0.05），同时胎儿血糖相应下降。对禁食动物的胎儿输注2小时葡萄糖后，FBMs显著增加至39.5%±4.9%，但尽管胎儿葡萄糖浓度比喂食对照值增加了两倍，FBMs发生率仅恢复到与喂食对照研究相似的水平。FBMs发生率的变化与胎儿低电压皮质电活动随葡萄糖变化的情况平行。总之，FBMs虽然与葡萄糖浓度相关，但可能受胎儿低血糖的影响大于高血糖。葡萄糖似乎通过改变低电压皮质电活动的发生率来影响FBMs的发生率。
