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产妇低血糖的潜在危害。

Potential hazards of hypoglycaemia in the parturient.

作者信息

Marx G F, Domurat M F, Costin M

出版信息

Can J Anaesth. 1987 Jul;34(4):400-2. doi: 10.1007/BF03010143.

DOI:10.1007/BF03010143
PMID:3608060
Abstract

Hypoglycaemia can cause serious problems in anaesthetized patients, due to blockade by anaesthesia of the usual compensatory mechanisms. Gravid women develop hypoglycaemia more readily than non-pregnant patients because they live in a state of "accelerated starvation." Three cases are described of healthy parturients undergoing elective Caesarean section under lumbar epidural analgesia whose post-blockade hypotension was difficult to reverse until their low blood glucose concentrations had been normalized. Further investigations of the role played by blood glucose concentrations in the maintenance of cardiovascular homeostasis in pregnant women are indicated. In the meantime, a preanaesthetic blood glucose determination will facilitate measures to ensure a normal blood glucose level before induction of anaesthesia for Caesarean section.

摘要

由于麻醉会阻断通常的代偿机制,低血糖会在麻醉患者中引发严重问题。与未怀孕的患者相比,孕妇更容易发生低血糖,因为她们处于“加速饥饿”状态。本文描述了3例健康产妇在腰段硬膜外镇痛下行择期剖宫产手术的情况,这些产妇在阻滞麻醉后出现低血压,在血糖浓度恢复正常之前,低血压很难纠正。这表明需要进一步研究血糖浓度在维持孕妇心血管稳态中所起的作用。同时,麻醉前测定血糖将有助于采取措施,确保剖宫产麻醉诱导前血糖水平正常。

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1
Potential hazards of hypoglycaemia in the parturient.产妇低血糖的潜在危害。
Can J Anaesth. 1987 Jul;34(4):400-2. doi: 10.1007/BF03010143.
2
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Anesthetic Considerations in the Obese Parturient.肥胖产妇的麻醉注意事项
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[Anaesthesia for Caesarean section].[剖宫产麻醉]
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[Combined epidural and spinal anesthesia for cesarean section].剖宫产联合硬膜外与脊髓麻醉
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Wrapping of the legs versus phenylephrine for reducing hypotension in parturients having epidural anaesthesia for caesarean section: a prospective, randomized and double-blind study.剖宫产硬膜外麻醉产妇中使用腿部包裹法与去氧肾上腺素预防低血压的比较:一项前瞻性、随机、双盲研究
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引用本文的文献

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Hypoglycemia enhances bupivacaine-induced cardiotoxicity in the rat.
J Anesth. 1992 Jul;6(3):255-61. doi: 10.1007/s0054020060255.

本文引用的文献

1
Effects of glucose concentration on fetal breathing movements and electrocortical activity in fetal lambs.葡萄糖浓度对胎羊胎儿呼吸运动和脑电活动的影响。
Am J Obstet Gynecol. 1982 Mar 15;142(6 Pt 1):678-83. doi: 10.1016/s0002-9378(16)32440-1.
2
Effects of intravenous glucose injections on human fetal breathing movements and gross fetal body movements at 38 to 40 weeks' gestational age.
Am J Obstet Gynecol. 1982 Mar 15;142(6 Pt 1):606-11. doi: 10.1016/s0002-9378(16)32427-9.
3
Effects of intrapartum maternal glucose infusion on the normal fetus and newborn.产时母体输注葡萄糖对正常胎儿及新生儿的影响。
Anesth Analg. 1982 Jan;61(1):32-5.
4
Maternal and neonatal blood glucose after crystalloid loading for epidural caesarean section.硬膜外剖宫产术晶体液预充后的母儿血糖情况
Anaesthesia. 1984 Dec;39(12):1240-2. doi: 10.1111/j.1365-2044.1984.tb06441.x.
5
Fetal and neonatal hazards of maternal hydration with 5% dextrose before caesarean section.剖宫产术前母体输注5%葡萄糖进行补液对胎儿及新生儿的危害
Lancet. 1982 May 22;1(8282):1150-2. doi: 10.1016/s0140-6736(82)92227-9.
6
Hypoglycemia in hospitalized patients. Causes and outcomes.住院患者的低血糖症。病因与后果。
N Engl J Med. 1986 Nov 13;315(20):1245-50. doi: 10.1056/NEJM198611133152002.
7
The incidence of gestational hypoglycemia in insulin-dependent and non-insulin-dependent diabetic women.胰岛素依赖型和非胰岛素依赖型糖尿病女性中妊娠低血糖的发生率。
N Y State J Med. 1986 Apr;86(4):174-7.
8
Carbohydrate metabolism in pregnancy. Part I. Diurnal plasma glucose profile in normal and diabetic women.孕期碳水化合物代谢。第一部分。正常及糖尿病女性的日间血糖谱
Br Med J. 1975 Aug 16;3(5980):399-402. doi: 10.1136/bmj.3.5980.399.
9
The blocking effect of epidural analgesia on the adrenocortical and hyperglycemic responses to surgery.硬膜外镇痛对手术所致肾上腺皮质反应及高血糖反应的阻滞作用。
Acta Anaesthesiol Scand. 1977;21(4):330-5. doi: 10.1111/j.1399-6576.1977.tb01227.x.