Sommer A, Emran N
Am J Ophthalmol. 1982 Jan;93(1):84-7. doi: 10.1016/0002-9394(82)90703-6.
Schirmer tests showed decreased tearing (less than 15 mm of wetting) in 32 of 54 eyes (59%) of a representative group of patients with corneal xerophthalmia but in only four of 60 eyes (7%) of age-, sex-, and neighborhood-matched controls (P less than .001). The occurrence of decreased tearing was directly related to protein status: eight of 18 eyes (44%) of children with serum transferrin levels below 50 mg/100 ml but only 13 of 62 eyes (21%) of children with higher levels produced less than 15 mm of wetting (P less than .01). Among otherwise well-nourished children, the occurrence of decreased tearing was directly related to the severity of xerophthalmia and thus to vitamin A status. We found decreased tearing in eight of 86 eyes (9%) of a group of unpaired controls, in nine of 38 eyes (24%) of children with conjunctival xerosis, and in 17 of 62 eyes (27%) of children with corneal involvement (P less than .01).
在一组具有代表性的角膜干燥症患者中，54只眼睛中有32只（59%）的泪液分泌试验显示泪液分泌减少（湿润长度小于15毫米），而在年龄、性别和社区匹配的对照组60只眼睛中，只有4只（7%）出现这种情况（P小于0.001）。泪液分泌减少的发生与蛋白质状态直接相关：血清转铁蛋白水平低于50毫克/100毫升的儿童中，18只眼睛有8只（44%）泪液分泌减少至小于15毫米，而水平较高的儿童中，62只眼睛只有13只（21%）出现这种情况（P小于0.01）。在其他营养状况良好的儿童中，泪液分泌减少的发生与干眼症的严重程度直接相关，因此也与维生素A状态相关。我们发现，在一组未配对的对照组86只眼睛中有8只（9%）泪液分泌减少，结膜干燥症儿童38只眼睛中有9只（24%），角膜受累儿童62只眼睛中有17只（27%）（P小于0.01）。
