Clark K E, Durnwald M, Austin J E
Am J Physiol. 1982 Feb;242(2):H297-301. doi: 10.1152/ajpheart.1982.242.2.H297.
A model is described for the investigation of the effects of acute and chronic reduction in uterine blood flow in unanesthetized pregnant sheep. An externally adjustable vascular occluder has been designed to utilize the principles of a modified Goldblatt clamp. This occluder is made of nonbreakable plastic and is adjusted via a flexible cable encased in a sheath. The occluder has been tested in 17 pregnant sheep and has remained functional for periods up to 36 days, the length of implantation. This occluder has allowed graded reductions in uterine blood flow, which can be accurately and consistently reproduced. An example of flow reduction is shown in which uterine blood flow has been reduced by 24, 47, and 82% in late-term pregnant sheep. This method will allow the investigation of the effects of uterine hypoperfusion and fetal hypoxia in a precisely controlled unanesthetized pregnant sheep preparation.
描述了一种用于研究未麻醉妊娠绵羊子宫血流量急性和慢性减少影响的模型。设计了一种外部可调节的血管闭塞器，以利用改良的戈德布拉特夹的原理。该闭塞器由不易破碎的塑料制成，并通过包裹在护套中的柔性电缆进行调节。该闭塞器已在17只妊娠绵羊中进行了测试，在长达36天的植入期内仍保持功能。该闭塞器可使子宫血流量分级减少，且可精确且一致地重现。给出了一个血流量减少的例子，其中晚期妊娠绵羊的子宫血流量分别减少了24%、47%和82%。该方法将允许在精确控制的未麻醉妊娠绵羊制备中研究子宫灌注不足和胎儿缺氧的影响。
