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[胎儿镜检查(作者译)]

[Fetoscopy (author's transl)].

作者信息

Rauskolb R, Fuhrmann W

出版信息

Z Geburtshilfe Perinatol. 1978 Aug;182(4):243-62.

PMID:706520
Abstract

It is the aim of fetoscopy to recognise or exclude malformations which are visible in the fetal stage and which are not associated with chromosomal damage. The requisite endoscope can be inserted practically without any problems into the amniotic cavity under local anaesthesia and in the manner of an "extended amniocentesis". If pregnancy is continued, the risk involed in fetoscopy must be assessed as similarly low as that of simple aminocentesis, as the clinical experience collected so far has shown. The clinical use of fetoscopy requires close co-operation with the geneticist and the parents concerned. The decision that fetoscopy is indicated lies mainly with the geneticist on account of the required expert genetic knowledge. Fetoscopy appears justified if there is an increased risk of malformation of the fetus which is manifest in the foetal stage and which is sufficiently serious to initiate therapeutic abortion if necessary, and, furthermore, if the risk involved in fetoscopy is in reasonable proportion to the risk of teh malformation. Over and above this, fetoscopy can also be justified if it is necessary to obtain fetal blood for examination. Satisfactory technical and endoscopic experience is the most important prerequisite for success and for reduced risk. Up to now, indication of fetoscopy was exclusively coupled to existing pregnancy and enhanced genetic risk. On the other hand, the question whether pregnancy should be permitted despite a known risk, simply because subsequent fetoscopy is envisaged, should be treated with reserve.

摘要

胎儿镜检查的目的是识别或排除在胎儿期可见且与染色体损伤无关的畸形。所需的内窥镜实际上可以在局部麻醉下以“扩展羊膜穿刺术”的方式毫无问题地插入羊膜腔。如果继续妊娠,正如目前收集的临床经验所示,胎儿镜检查所涉及的风险必须评估为与简单羊膜穿刺术的风险同样低。胎儿镜检查的临床应用需要与遗传学家和相关父母密切合作。由于需要专业的遗传知识,胎儿镜检查是否适用的决定主要由遗传学家做出。如果胎儿畸形风险增加,这种风险在胎儿期就已显现,且严重到必要时可引发治疗性流产,此外,如果胎儿镜检查所涉及的风险与畸形风险成合理比例,那么进行胎儿镜检查似乎是合理的。除此之外,如果有必要获取胎儿血液进行检查,胎儿镜检查也是合理的。令人满意的技术和内窥镜经验是成功及降低风险的最重要前提。到目前为止,胎儿镜检查的适应症仅与现有妊娠及增加的遗传风险相关。另一方面,对于仅仅因为设想了后续的胎儿镜检查就不顾已知风险是否应允许妊娠的问题,应持谨慎态度。

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