Rascher W, Lang R E, Unger T, Ganten D, Gross F
Am J Physiol. 1982 Apr;242(4):H496-9. doi: 10.1152/ajpheart.1982.242.4.H496.
In stroke-prone spontaneously hypertensive rats (SHRSP) and in normotensive Wistar-Kyoto rats (WKY), arginine vasopressin (AVP) was measured by means of a radioimmunoassay in the plasma, the pituitary gland, the hypothalamus, and the brain stem. In 6- and 14-wk-old SHRSP, the plasma concentration of AVP was lower than in age-matched WKY (P less than 0.01), whereas it was elevated at 28 wk of age (P less than 0.01). In the pituitary of 6-wk-old SHRSP, AVP was higher than in WKY (P less than 0.05), but no such difference was found in older rats. In the hypothalamus and the brain stem, AVP content was reduced in all age groups of SHRSP. Plasma osmolality was diminished in 28-wk-old SHRSP only (P less than 0.01), whereas hematocrit in all age groups was higher in SHRSP than in WKY. It is concluded that the secretion of AVP and possibly its synthesis in the hypothalamus are reduced in SHRSP. Whether the reduced AVP content in the brain stem is related to the sustained elevation of blood pressure has to be studied further.
在易患中风的自发性高血压大鼠（SHRSP）和正常血压的Wistar-Kyoto大鼠（WKY）中，通过放射免疫分析法测定血浆、垂体、下丘脑和脑干中的精氨酸加压素（AVP）。在6周龄和14周龄的SHRSP中，AVP的血浆浓度低于年龄匹配的WKY（P<0.01），而在28周龄时升高（P<0.01）。在6周龄SHRSP的垂体中，AVP高于WKY（P<0.05），但在老年大鼠中未发现这种差异。在SHRSP的所有年龄组中，下丘脑和脑干中的AVP含量均降低。仅在28周龄的SHRSP中血浆渗透压降低（P<0.01），而SHRSP所有年龄组的血细胞比容均高于WKY。得出的结论是，SHRSP中AVP的分泌以及可能在下丘脑中的合成减少。脑干中AVP含量的降低是否与血压的持续升高有关，还有待进一步研究。
