Keller M B, Shapiro R W
Am J Psychiatry. 1982 Apr;139(4):438-42. doi: 10.1176/ajp.139.4.438.
Although "double depression"--major depressive disorder superimposed on an underlying chronic depression--is a frequent phenomenon, the concept has not been well formulated clinically and has rarely been described in the research literature. The authors found that 1) 26% of l0l patients who met the criteria for major depressive disorder had an underlying chronic depressive disorder of at least 2 years' duration, 2) "recovery" rates for patients with superimposed depression differed greatly depending on whether recovery was defined as recovery from the major depressive disorder only or recovery from both disorders, and 3) patients with superimposed depression relapsed at a significantly higher rate immediately after recovery from the acute episode of depression than did patients without superimposed depression.
尽管“双重抑郁”——即重度抑郁症叠加在潜在的慢性抑郁症之上——是一种常见现象,但这一概念在临床上尚未得到很好的阐述,在研究文献中也很少被描述。作者发现:1)101名符合重度抑郁症标准的患者中,26%有至少持续两年的潜在慢性抑郁症;2)叠加性抑郁症患者的“康复”率差异很大,这取决于康复是仅定义为从重度抑郁症中康复,还是从两种疾病中康复;3)叠加性抑郁症患者在从抑郁症急性发作中康复后,立即复发的比率明显高于无叠加性抑郁症的患者。