Schubert D S, Brocco K, Miller F T, Patterson M
Am J Psychiatry. 1982 Apr;139(4):491-3. doi: 10.1176/ajp.139.4.491.
In this study 18 patients with a research diagnostic criteria diagnosis of schizophrenia had a mean initial serum creatine phosphokinase level significantly higher than that of 36 control subjects with other RDC diagnoses. There were no corresponding elevations in the serum levels of nondrinking alcoholics or patients with primary or secondary affective disorders. The authors suggest that increased creatine phosphokinase levels in schizophrenic patients may be due to a sudden increase in the substance in the dopaminergic or limbic system due to increased muscle membrane permeability or to sympathetic nervous system or adrenergic dominance.
在本研究中，18例根据研究诊断标准被诊断为精神分裂症的患者，其初始血清肌酸磷酸激酶水平均值显著高于36例患有其他研究诊断标准（RDC）诊断疾病的对照受试者。不饮酒者、原发性或继发性情感障碍患者的血清水平没有相应升高。作者认为，精神分裂症患者肌酸磷酸激酶水平升高可能是由于多巴胺能或边缘系统中该物质因肌膜通透性增加、交感神经系统或肾上腺素能占优势而突然增加所致。
