Creatine phosphokinase elevations and psychiatric symptomatology.

The authors retrospectively studied 322 patient-admissions to the ward service of a psychiatric hospital for the period of 1 year. Twenty-five acutely psychotic patients were found who had unexplained elevations of serum creatine phosphokinase (CPK); 14 of the 25, (56%) had either a research or a clinical diagnosis of primary affective disorder, bipolar type (mania). Similar findings of CPK elevations and acute psychosis by other authors are described.