Hakamada S, Watanabe K, Hara K, Miyazaki S, Kumagai T
Brain Dev. 1982;4(1):51-5. doi: 10.1016/s0387-7604(82)80101-0.
Body movements during sleep were observed in 14 full-term sick newborn infants such as perinatal asphyxia, purulent meningitis, meconium aspiration syndrome, melena, porencephaly, and hydranencephaly. Five newborn infants who had recovered from transient vomiting were examined as control. Infants with minimally depressed background EEG showed an increase of generalized movement (GM) and localized tonic movement (LTM) in quiet sleep. Hydranencephalic infants revealed an increase of generalized phasic movement (GPM) in active and quiet sleep. On the other hand, a decrease or an absence of body movements was observed in infants with severe EEG abnormalities such as moderate, marked and maximal depression. Hydranencephalic and porencephalic neonates showed a decrease of LTM in active sleep. One infant with purulent meningitis, showing markedly depressed EEG, revealed GPM-like movements of much longer duration. The follow-up study revealed that the absence of body movements or the increase of GPM might indicate a very poor outcome, whereas the presence of LTM, even in a small amount, suggested the preservation of cortical functions. The increase of body movements was also considered to correlate with sleep disturbance and served to indicate a brain dysfunction.
对14名患有围产期窒息、化脓性脑膜炎、胎粪吸入综合征、黑便、孔洞脑、积水性无脑畸形等疾病的足月患病新生儿在睡眠期间的身体运动进行了观察。选取5名已从短暂呕吐中康复的新生儿作为对照。背景脑电图轻度抑制的婴儿在安静睡眠中全身运动（GM）和局部强直性运动（LTM）增加。积水性无脑畸形婴儿在主动睡眠和安静睡眠中全身相运动（GPM）增加。另一方面，脑电图有严重异常如中度、明显和极度抑制的婴儿，观察到身体运动减少或缺失。积水性无脑畸形和孔洞脑新生儿在主动睡眠中LTM减少。一名患有化脓性脑膜炎且脑电图明显抑制的婴儿，出现了持续时间长得多的类似GPM的运动。随访研究表明，身体运动缺失或GPM增加可能预示预后极差，而LTM的存在，即使数量很少，也提示皮质功能得以保留。身体运动增加也被认为与睡眠障碍相关，提示存在脑功能障碍。
