Franke N, Endrich B, Laubenthal H, Peter K, Messmer K
Anasth Intensivther Notfallmed. 1982 Feb;17(1):11-4.
The effects of pentobarbitone anaesthesia on the macrohaemodynamics and the microvasculature of subcutaneous tissue and skin muscle were studied in hamsters (n = 14) utilizing intravital microscopy, quantitative video techniques and a platinum multiwire electrode for local PO2 measurements. After achieving anaesthesia with 35 mg/kg b.w. pentobarbitone, changes in macrohaemodynamic parameters, blood cell velocity and vessel diameters were not observed. However, after 30 min of pentobarbitone anaesthesia, 25% of the arteriolar blood volume coursed through arteriovenous shunts. The increase in a-v shunting was accompanied by a significant decrease of functional capillary density. As a result, local PO2 values decreased slightly after 30 min of pentobarbitone anaesthesia. These findings provide evidence that 35 mg/kg b.w. pentobarbitone cause alterations in capillary density and perfusion. It is concluded that with a dose of up to 35 mg/kg b.w. pentobarbitone, these changes have little effect on local tissue oxygenation.
利用活体显微镜、定量视频技术和用于局部氧分压测量的铂多丝电极，研究了戊巴比妥麻醉对仓鼠（n = 14）的宏观血流动力学以及皮下组织和皮肤肌肉微血管系统的影响。以35 mg/kg体重的戊巴比妥实现麻醉后，未观察到宏观血流动力学参数、血细胞速度和血管直径的变化。然而，在戊巴比妥麻醉30分钟后，25%的小动脉血容量通过动静脉分流。动静脉分流增加的同时，功能性毛细血管密度显著降低。结果，戊巴比妥麻醉30分钟后局部氧分压值略有下降。这些发现证明35 mg/kg体重的戊巴比妥会导致毛细血管密度和灌注的改变。得出的结论是，使用高达35 mg/kg体重的戊巴比妥剂量时，这些变化对局部组织氧合影响很小。
