Hamminga B, Noordijk E M, van Vloten W A
Arch Dermatol. 1982 Mar;118(3):150-3. doi: 10.1001/archderm.118.3.150.
Of 42 patients who had mycosis fungoides (MF) confined to the skin with or without dermatopathic lymphadenopathy, 21 were treated with topically applied mechlorethamine hydrochloride and 21 with total-skin electron-beam irradiation. The results of both therapeutic modalities are compared. We conclude that, in the early stage of the disease, both forms of treatment are equally effective. In the later stages of MF, in the absence of lymph node or other systemic involvement, electron-beam irradiation seems to be superior in inducing an initial complete remission. However, because of the large number of patients who have a relapse after this therapy, it should be followed by topical mechlorethamine therapy.
在42例蕈样肉芽肿（MF）局限于皮肤伴或不伴皮肤型淋巴结病的患者中，21例接受局部应用盐酸氮芥治疗，21例接受全身皮肤电子束照射治疗。对两种治疗方式的结果进行了比较。我们得出结论，在疾病早期，两种治疗方式同样有效。在MF后期，在无淋巴结或其他全身受累的情况下，电子束照射在诱导初始完全缓解方面似乎更具优势。然而，由于大量患者在此治疗后会复发，因此应继以局部氮芥治疗。
