Ratcliffe S G, Bancroft J, Axworthy D, McLaren W
Arch Dis Child. 1982 Jan;57(1):6-12.
Twelve boys with Klinefelter's syndrome (47,XXY) identified by sex chromatin screening at birth were examined at between ages 16 and 18 years, together with 12 controls matched for social class and birth order from the same newborn population. Physical examination, psychometric assessment, personality, and degree of psychosexual development were assessed without knowledge of the karyotype. Anthropometry showed increased leg length and decreased head circumference in the XXY boys. Gynaecomastia was present in 4 boys, and testicular volume was reduced in the majority but one boy had normal sized testes. On the Wechsler intelligence scale there was a significant reduction in verbal score but not in either performance or full-scale score compared with the controls. Although appreciable differences were found in growth, personality, intelligence test scores, and psychosexual development, these were of small degree.
通过出生时的性染色质筛查确定的12名患有克兰费尔特综合征（47,XXY）的男孩，在16至18岁之间接受了检查，同时还有12名来自同一新生儿群体的对照者，这些对照者在社会阶层和出生顺序方面与之匹配。在不知道核型的情况下，对体格检查、心理测量评估、性格和性心理发育程度进行了评估。人体测量显示XXY男孩的腿长增加，头围减小。4名男孩有乳腺增生，大多数男孩的睾丸体积减小，但有一名男孩的睾丸大小正常。与对照组相比，韦氏智力量表的言语分数显著降低，但操作分数或总分数没有降低。虽然在生长、性格、智力测试分数和性心理发育方面发现了明显差异，但程度较小。
