Gabutti V, Piga A, Nicola P, Vullo C, Capra L, Di Palma A, Masera G, Terzoli S, Mauri R
Arch Dis Child. 1982 Feb;57(2):156-8. doi: 10.1136/adc.57.2.156.
The relationship between blood requirement and the mean level of maintained haemoglobin was examined in 392 patients with homozygous beta-thalassaemia. Pre- and post-transfusional haemoglobin levels and the amounts of blood transfused were measured during a 1-year period. No significant differences were noted in the blood requirements of patients (splenectomised or not) irrespective of the haemoglobin level. It may be supposed that if the mean haemoglobin level is high the haematopoietic activity is inhibited, and hence the bone marrow mass and total blood volume are reduced. High haemoglobin levels may thus be obtained with no increase in blood intake.
在392例纯合子β地中海贫血患者中研究了血液需求量与维持的血红蛋白平均水平之间的关系。在1年期间测量了输血前后的血红蛋白水平及输血量。无论血红蛋白水平如何，（脾切除或未脾切除的）患者的血液需求量均未发现显著差异。可以推测，如果血红蛋白平均水平较高，造血活性会受到抑制，从而骨髓量和总血容量会减少。因此，可不增加血液摄入量而维持较高的血红蛋白水平。
