Tsuang M T, Simpson J C, Kronfol Z
Arch Gen Psychiatry. 1982 Feb;39(2):141-7. doi: 10.1001/archpsyc.1982.04290020013003.
Hospital records of 72 drug abusers with psychoses (DAP) were analyzed to clarify the relationship between drug abuse and psychosis. Comparison groups included schizophrenics and atypical schizophrenics without drug abuse and drug abusers without psychoses (DA). Compared with DAP in whom psychoses lasted less than six months before admission (DAP-short), drug abusers with psychoses of a longer duration (DAP-long) had more symptoms, more premorbid personality disorders, and greater familial risks of schizophrenia and affective disorder. The DAP-long group resembled atypical schizophrenia for clinical features and family history, whereas the DAP-short group resembled DA for some clinical features and family history. The results indicate that there are several subgroups of DAP. The importance of clinical features and family history in identifying subgroups of DAP was stressed.
对72名患有精神病的药物滥用者（DAP）的医院记录进行了分析，以阐明药物滥用与精神病之间的关系。对照组包括未滥用药物的精神分裂症患者和非典型精神分裂症患者，以及未患精神病的药物滥用者（DA）。与入院前精神病持续时间少于6个月的DAP（DAP-短期）相比，精神病持续时间较长的药物滥用者（DAP-长期）有更多症状、更多病前人格障碍，以及更高的精神分裂症和情感障碍家族风险。DAP-长期组在临床特征和家族史方面类似于非典型精神分裂症，而DAP-短期组在一些临床特征和家族史方面类似于DA。结果表明，DAP存在几个亚组。强调了临床特征和家族史在识别DAP亚组中的重要性。
