Stancer H C, Persad E
Arch Gen Psychiatry. 1982 Mar;39(3):311-2. doi: 10.1001/archpsyc.1982.04290030045008.
Hypermetabolic doses of levothyroxine sodium produced remissions in five of seven women with intractable manic-depressive illness who were followed up for nine months to nine years. These patients had previously required long-term or frequent psychiatric hospitalization. The onset of illness was during the postpartum or involutional period and soon developed into cycles of four or more episodes yearly that did not respond to therapy with lithium carbonate, antidepressants, or neuroleptics. The levothyroxine treatment was unsuccessful in two men and one adolescent girl.
超代谢剂量的左甲状腺素钠使7名患有难治性躁郁症的女性中的5名病情缓解，对她们进行了9个月至9年的随访。这些患者此前需要长期或频繁的精神科住院治疗。发病于产后或更年期，很快发展为每年发作4次或更多次的循环发作，对碳酸锂、抗抑郁药或抗精神病药物治疗均无反应。左甲状腺素治疗对2名男性和1名青春期女孩无效。
