Wexler B C, McMurtry J P
Br J Exp Pathol. 1982 Feb;63(1):66-81.
Male and female, normotensive, Sprague-Dawley (S-D), Wistar-Kyoto (WKy), and spontaneously hypertensive rats (SHR) were bred repeatedly until the females had given birth to and nursed 6 litters of pups. At the close of the 2nd, 4th and 6th breeding, breeder males and females, along with celibate males and females of equal age, were killed. S-D and WKy breeder rats manifested progressively increasing adiposity and high blood pressure with each successive breeding; breeder SHR showed mild exacerbation of their pre-existing high blood pressure. Adrenocortical hyperplasia and thymus-gland involution suggested increasing pituitary-adrenal activity in breeder rats. Circulating aldosterone levels decreased with repeated breeding in parallel with increased deoxycorticosterone and corticosterone secretion. The repeatedly bred normotensive rats manifested worsening aortic sclerosis as against little or no aortic sclerosis in the repeatedly bred SHR. Breeder SHR developed fibrinohyalin intimal lesions limited exclusively to the arterioles of the testis and ovary. Virgin rats did not develop any vascular disease. It is suggested that a diverse spectrum of adrenal steroids in breeder HSR combined with genetic direction control the morphogenesis of arterial disease in breeder SHR.
选用雄性和雌性的正常血压的斯普拉格-道利（S-D）大鼠、Wistar-Kyoto（WKy）大鼠和自发性高血压大鼠（SHR），反复进行繁殖，直至雌性大鼠产下并哺育6窝幼崽。在第2次、第4次和第6次繁殖结束时，处死繁殖用的雄性和雌性大鼠，以及同龄的未交配的雄性和雌性大鼠。S-D和WKy繁殖用大鼠每次繁殖后肥胖程度和血压都逐渐增加；繁殖用SHR大鼠原有高血压症状稍有加重。肾上腺皮质增生和胸腺萎缩表明繁殖用大鼠垂体-肾上腺活动增强。随着繁殖次数的增加，循环中的醛固酮水平下降，同时脱氧皮质酮和皮质酮分泌增加。反复繁殖的正常血压大鼠主动脉硬化加重，而反复繁殖的SHR大鼠主动脉硬化很少或没有。繁殖用SHR大鼠出现纤维透明样内膜病变，仅局限于睾丸和卵巢的小动脉。未交配的大鼠未出现任何血管疾病。提示繁殖用SHR大鼠中多种肾上腺类固醇与遗传因素共同控制动脉疾病的形态发生。
