Wexler B C, Iams S G, Judd J T
Circ Res. 1976 Jun;38(6):494-501. doi: 10.1161/01.res.38.6.494.
Repeatedly bred male and female rats of many strains develop hyperglycemia, hyperlipidemia, hypertension, and arteriosclerosis spontaneously. The intensity of their arterial disease and related metabolic derangements appear to be related to their reproductive activity. Repeatedly bred spontaneously hypertensive rats (SHR) were found to have severe hypertension, hyperglycemia, hyperlipidemia, elevated creatine phosphokinase (CPK), serum glutamic oxaloacetic and glutamic pyruvic transaminase (SGOT, SGPT), and lactic dehydrogenase (LDH), as well as high circulating corticosterone levels. Despite these atherogenic metabolic derangements and their severe hypertension, the breeder SHR did not develop the severe, generalized arteriosclerosis found in other strains of breeder rats. Instead, the arterial lesions, consisting of intimal hyalinization and fibrosis, medial hypertrophy, and occlusion of the lumen, were found only in male breeder SHR and were confined to the intratubular arteries of the testes. It is suggested that the severe hypertension, genetic influences, or differences in hypothalamic-pituitary-adrenal-gonadal function in breeder SHR may not have been conducive to the development of arteriosclerosis in this particular strain of rats.
许多品系的经多次繁殖的雄性和雌性大鼠会自发出现高血糖、高血脂、高血压和动脉硬化。它们动脉疾病的严重程度以及相关的代谢紊乱似乎与它们的生殖活动有关。研究发现，经多次繁殖的自发性高血压大鼠（SHR）患有严重的高血压、高血糖、高血脂，肌酸磷酸激酶（CPK）、血清谷草转氨酶和谷丙转氨酶（SGOT、SGPT）以及乳酸脱氢酶（LDH）升高，同时循环皮质酮水平也很高。尽管存在这些致动脉粥样硬化的代谢紊乱以及严重的高血压，但繁殖用SHR并未出现其他品系繁殖用大鼠中所发现的严重的全身性动脉硬化。相反，仅在雄性繁殖用SHR中发现了由内膜玻璃样变和纤维化、中膜肥厚以及管腔闭塞组成的动脉病变，且局限于睾丸的管内动脉。有人提出，繁殖用SHR中的严重高血压、遗传影响或下丘脑 - 垂体 - 肾上腺 - 性腺功能差异可能不利于该特定品系大鼠动脉硬化的发展。
