Vega F A, Halprin K M, Taylor J R, Woodyard C, Comerford M
Br J Dermatol. 1982 Mar;106(3):361-6. doi: 10.1111/j.1365-2133.1982.tb01737.x.
We have reported that prior ultraviolet radiation (UVR) exposure significantly delayed development of contact sensitivity to nitrogen mustard (Halprin et al., 1981). We felt that this effect was due to disruption of functional Langerhans cells in skin by UVR and suggested that periodic UVR treatments might prevent sensitization to the mustard. We now report on a patient with mycosis fungoides whose epidermal Langerhans cell count was monitored with the ATP-ase stain in order to determine when such 'booster" UVR therapy was to be given. Our attempts to interfere with Langerhans cell function in this manner failed to prevent delayed contact sensitivity to nitrogen mustard and may have been partly responsible for the development of contact urticaria to nitrogen mustard after 28 days of use. Whether the reaction was a delayed, cell-mediated reaction, or an antibody mediated reaction is not clear, but the use of UVR did fail to prevent contact sensitivity to the nitrogen mustard in our patient.
我们曾报道，先前的紫外线辐射（UVR）暴露显著延迟了对氮芥的接触敏感性的发展（哈尔普林等人，1981年）。我们认为这种效应是由于UVR对皮肤中功能性朗格汉斯细胞的破坏所致，并提出定期进行UVR治疗可能会预防对芥子气的致敏。我们现在报告一名蕈样肉芽肿患者，其表皮朗格汉斯细胞计数通过ATP酶染色进行监测，以确定何时给予这种“增强”UVR治疗。我们以这种方式干扰朗格汉斯细胞功能的尝试未能预防对氮芥的延迟接触敏感性，并且可能部分导致了在使用28天后对氮芥发生接触性荨麻疹。尚不清楚该反应是延迟的细胞介导反应还是抗体介导反应，但UVR的使用确实未能预防我们患者对氮芥的接触敏感性。
