Lee L A, Fritz K A, Golitz L, Fritz T J, Weston W L
J Am Acad Dermatol. 1982 Nov;7(5):590-8. doi: 10.1016/s0190-9622(82)70138-0.
Previous reports of skin cancer occurring in mycosis fungoides patients who have been treated with topical nitrogen mustard have been of carcinomas occurring predominantly on sun-exposed skin. Four of twenty-nine mycosis fungoides patients in our clinic treated with topical nitrogen mustard developed six skin cancers on sun-protected skin. Four lesions were squamous cell carcinomas and two were basal cell carcinomas. Few other risk factors for the development of skin cancer were present in our patients. These cases support the hypothesis that topical nitrogen mustard is a carcinogen or tumor promote and emphasize the need for careful examination of the skin of patients treated with topical nitrogen mustard.
先前关于接受局部氮芥治疗的蕈样肉芽肿患者发生皮肤癌的报道，主要是发生在阳光暴露皮肤上的癌。在我们诊所接受局部氮芥治疗的29例蕈样肉芽肿患者中，有4例在防晒皮肤上发生了6例皮肤癌。4处损害为鳞状细胞癌，2处为基底细胞癌。我们的患者中几乎没有其他皮肤癌发生的风险因素。这些病例支持局部氮芥是一种致癌物或肿瘤促进剂的假说，并强调需要仔细检查接受局部氮芥治疗患者的皮肤。
