缺铁指标对红细胞增多症患者全血黏度的影响。

The influence of iron-deficient indices on whole blood viscosity in polycythaemia.

作者信息

Milligan D W, MacNamee R, Roberts B E, Davies J A

出版信息

Br J Haematol. 1982 Mar;50(3):467-71. doi: 10.1111/j.1365-2141.1982.tb01942.x.

DOI:10.1111/j.1365-2141.1982.tb01942.x

Abstract

The relationship of the red-cell indices, packed-cell volume (PCV) and plasma viscosity to whole-blood viscosity was examined in 18 patients with polycythaemia. Sixteen were examined again following a course of venesection. The results were analysed by multiple regression analysis which allowed the effects of individual variables to be independently assessed. A reduction of the MCH or MCV was associated with increased whole-blood viscosity especially at low-shear rates. It is concluded that the reduced size of iron-deficient cells results in increased cell-cell interaction causing an increase in whole-blood viscosity.

摘要

对18例红细胞增多症患者的红细胞指数、血细胞比容（PCV）和血浆粘度与全血粘度之间的关系进行了研究。其中16例患者在进行了一个疗程的静脉切开放血术后再次接受检查。通过多元回归分析对结果进行分析，该分析可独立评估各个变量的影响。平均红细胞血红蛋白含量（MCH）或平均红细胞体积（MCV）降低与全血粘度增加有关，尤其是在低剪切速率下。得出的结论是，缺铁细胞体积减小导致细胞间相互作用增加，从而使全血粘度升高。