Van de Pette J E, Guthrie D L, Pearson T C
Br J Haematol. 1986 Jun;63(2):369-75. doi: 10.1111/j.1365-2141.1986.tb05562.x.
The effect of iron deficient red cells changes (MCH range 20.0-32.6 pg) on whole blood viscosity (WBV) at high and low shear rates (94.5 and 0.51 s-1), has been assessed at a wide range of standardized PCV (0.30-0.65) and standardized Hb values (10.0-22.0 g/dl). Particular attention was given to the precision of PCV measurement. At all PCV values there was no correlation between MCH and WBV, whereas at all Hb values there was a significant negative correlation between MCH and WBV. If the treatment of polycythaemia is by venesection, iron deficient red cell changes occur frequently. These changes are unimportant if control of the WBV is the objective of treatment, as long as the PCV is accurately measured. Alternatively, in the secondary polycythaemias, where oxygen saturation is reduced, the induction of iron deficient red cell changes could be regarded as disadvantageous since at a standard PCV of 0.50 the Hb and hence oxygen carrying capacity is reduced by approximately 11% between MCH values of 30 and 20 pg.
在一系列标准化的红细胞压积（0.30 - 0.65）和标准化血红蛋白值（10.0 - 22.0 g/dl）条件下，评估了缺铁红细胞变化（平均红细胞血红蛋白含量范围为20.0 - 32.6 pg）对高、低剪切率（94.5和0.51 s-1）下全血粘度（WBV）的影响。特别关注了红细胞压积测量的精度。在所有红细胞压积值下，平均红细胞血红蛋白含量与全血粘度之间均无相关性，而在所有血红蛋白值下，平均红细胞血红蛋白含量与全血粘度之间均存在显著负相关。如果通过静脉放血治疗红细胞增多症，缺铁红细胞变化经常发生。如果治疗目标是控制全血粘度，只要准确测量红细胞压积，这些变化并不重要。另外，在继发性红细胞增多症中，由于氧饱和度降低，缺铁红细胞变化的诱导可能被视为不利，因为在标准红细胞压积为0.50时，平均红细胞血红蛋白含量在30和20 pg之间变化时，血红蛋白以及携氧能力会降低约11%。
