Read A P, Fennell S J, Donnai D, Harris R
Br J Obstet Gynaecol. 1982 Feb;89(2):111-6. doi: 10.1111/j.1471-0528.1982.tb04675.x.
After retrospective evaluation with stored samples, the qualitative acetylcholinesterase (AChE) test has been used prospectively in conjunction with alpha-fetoprotein (AFP) assay on 986 amniotic fluid specimens received in this laboratory during 1980. The main value of AChE is in classifying fluids in which the AFP level is near the threshold between normal and abnormal. Among abnormal pregnancies with raised AFP levels, neural-tube defects can generally be distinguished from other abnormalities by careful appraisal of the AChE gel pattern, but confirmation of these other fetal abnormalities may require high resolution diagnostic ultrasonography and perhaps fetoscopy. Neural-tube defects with false negative AFP levels can be detected by AChE, but AChE gives occasional false positives so that it cannot be relied on in isolation for the diagnosis of neural-tube defects.
在用储存样本进行回顾性评估后，定性乙酰胆碱酯酶（AChE）检测已与甲胎蛋白（AFP）检测联合，前瞻性地应用于1980年本实验室收到的986份羊水标本。AChE的主要价值在于对AFP水平接近正常与异常阈值的羊水进行分类。在AFP水平升高的异常妊娠中，通过仔细评估AChE凝胶图谱，神经管缺陷通常可与其他异常区分开来，但要确诊这些其他胎儿异常可能需要高分辨率诊断超声检查，甚至可能需要胎儿镜检查。AFP水平呈假阴性的神经管缺陷可通过AChE检测出来，但AChE偶尔会出现假阳性结果，因此不能单独依靠它来诊断神经管缺陷。
