Gast K, Zirwer D, Ladhoff A M, Schreiber J, Koelsch R, Kretschmer K, Lasch J
Biochim Biophys Acta. 1982 Mar 23;686(1):99-109. doi: 10.1016/0005-2736(82)90155-9.
Spontaneous size changes of small unilamellar vesicles with initial mean diameters of 25 nm measured by quasi-elastic light scattering (QELS) and electron microscopy are reported. After the size conversion the vesicles have mean diameters of about 70 nm and are of the unilamellar and multilamellar type. The fact that auto-oxidation initiates this process is established by the comparison of the results for vesicles which differ only in the degree of auto-oxidation. The role of phosphatidylcholine hydroperoxides as fusogens is discussed.
报道了通过准弹性光散射（QELS）和电子显微镜测量的初始平均直径为25nm的小单层囊泡的自发尺寸变化。尺寸转变后，囊泡的平均直径约为70nm，为单层和多层类型。通过比较仅在自氧化程度上不同的囊泡的结果，证实了自氧化引发这一过程。讨论了磷脂酰胆碱氢过氧化物作为融合剂的作用。
