[Enzymes of the detoxication of active forms of oxygen and lipoperoxides in experimental ischemia and myocardial infarct].

Variation in the activity of superoxide dismutase, glutathione peroxidase (tretbutyl hydroperoxide as a substrate) and glutathione-S-transferase (1-chloro-2,4-dinitrobenzene as a substrate) was studied in rat ischemia and in coronaro-occlusion myocardial infarction. The activity of superoxide dismutase and glutathione peroxidase drastically reduced 2-15 minutes after ligation of the coronary artery and remained at the decreased level during the observation period (14 days). The activity of glutathione-S-transferase in the infarcted zone of the myocardium significantly decreased only by day 3 of the experiment. The activity of glutathione peroxidase in the blood of patients with acute myocardial infarction rose more than 1.5-fold.