牛磺酸对兔耳动脉高钾和去甲肾上腺素诱导收缩的影响。
The effect of taurine on high potassium-and noradrenaline-induced contraction in rabbit ear artery.
作者信息
Franconi F, Giotti A, Manzini S, Martini F, Stendardi I, Zilletti L
出版信息
Br J Pharmacol. 1982 Apr;75(4):605-12. doi: 10.1111/j.1476-5381.1982.tb09180.x.
Abstract
1 Intraluminal administration of taurine (40 mM) did not affect the contractile tone of rabbit isolated ear artery 2 Taurine (10-80 mM) exerted a powerful concentration-dependent, vasodilator action in arteries contracted with high potassium medium. 3 In the same experimental conditions, the taurine analogues beta-alanine and homotaurine, had no effect. 4 Taurine (40-80 mM) did not affect in a significant manner the tonic component of the noradrenaline (5x10(-6 M)-induced contraction. 5 When noradrenaline (5x10(-6M) was followed by the administration of high potassium medium a further increase in intraluminal pressure was observed. Under these conditions taurine (40 mM) reversed specifically the component due to the high potassium medium.
摘要
向家兔离体耳动脉管腔内注射牛磺酸（40 mM）对其收缩张力无影响。
牛磺酸（10 - 80 mM）对用高钾培养基收缩的动脉具有强大的浓度依赖性血管舒张作用。
在相同实验条件下，牛磺酸类似物β - 丙氨酸和高牛磺酸无作用。
牛磺酸（40 - 80 mM）对去甲肾上腺素（5×10⁻⁶ M）诱导的收缩的张力成分无显著影响。
当去甲肾上腺素（5×10⁻⁶ M）之后给予高钾培养基时，观察到管腔内压力进一步升高。在这些条件下，牛磺酸（40 mM）特异性地逆转了由高钾培养基引起的成分。
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