School of Health, Sport and Applied Sciences, St Mary's University, London, TW1 4SX, UK.
School of Science and Technology, University of New England, Armidale, NSW, 2350, Australia.
Curr Hypertens Rep. 2018 Jul 13;20(9):81. doi: 10.1007/s11906-018-0881-z.
The aims of this meta-analysis were to investigate the effects of orally administered isolated taurine on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in humans.
There is growing evidence that taurine deficiency is associated with hypertension and that oral supplementation can have antihypertensive effects in humans. However, these investigations have been conducted across a number of decades and populations and have not been collectively reviewed. A search was performed using various databases in May 2018 and later screened using search criteria for eligibility. There were seven peer-reviewed studies meeting the inclusion criteria, encompassing 103 participants of varying age and health statuses. Taurine ingestion reduced SBP (Hedges' g = - 0.70, 95% CI - 0.98 to - 0.41, P < 0.0001) and DBP (Hedges' g = - 0.62, 95% CI - 0.91 to - 0.34, P < 0.0001). These results translated to mean ~ 3 mmHg reductions in both SBP (range = 0-15 mmHg) and DBP (range = 0-7 mmHg) following a range of doses (1 to 6 g/day) and supplementation periods (1 day to 12 weeks), with no adverse events reported. These preliminary findings suggest that ingestion of taurine at the stated doses and supplementation periods can reduce blood pressure to a clinically relevant magnitude, without any adverse side effects. Future studies are needed to establish the effects of oral taurine supplementation on targeted pathologies and the optimal supplementation doses and periods.
本荟萃分析的目的是研究口服分离牛磺酸对人体静息收缩压（SBP）和舒张压（DBP）的影响。
越来越多的证据表明，牛磺酸缺乏与高血压有关，口服补充牛磺酸对人体具有降压作用。然而，这些研究已经进行了几十年，涉及不同的人群，尚未进行综合审查。2018 年 5 月，我们使用各种数据库进行了搜索，然后根据入选标准进行了筛选。符合纳入标准的有 7 项同行评议研究，共纳入 103 名不同年龄和健康状况的参与者。牛磺酸摄入降低 SBP（Hedges'g=-0.70，95%置信区间-0.98 至-0.41，P<0.0001）和 DBP（Hedges'g=-0.62，95%置信区间-0.91 至-0.34，P<0.0001）。这些结果转化为 SBP（范围 0-15mmHg）和 DBP（范围 0-7mmHg）的平均降低约 3mmHg，在不同剂量（1-6g/天）和补充期（1 天至 12 周）下，均无不良事件报告。这些初步发现表明，在规定剂量和补充期内摄入牛磺酸可将血压降低到临床相关的程度，且无任何不良副作用。需要进一步的研究来确定口服牛磺酸补充剂对特定病理的影响，以及最佳的补充剂量和时间。
