Ekblom P, Sariola H, Karkinen-Jääskeläinen M, Saxén L
Cell Differ. 1982 Jan;11(1):35-9. doi: 10.1016/0045-6039(82)90014-8.
The origin of the glomerular endothelium has remained unsettled, although it has mostly been assumed that it is derived from the metanephric mesenchyme, like, the other parts of the nephron. Since our recent observations did not support this concept, the development of the vasculature of the kidney and of the glomerular endothelium was studied using both mouse/quail and quail/chick interspecies grafts. Undifferentiated 11-day mouse kidney anlagen were transplanted onto quail chorioallantoic membrane and allowed to develop for 7-10 days. Upon examination, grafts were well-vascularized, and both the glomerular and the vessel endothelium expressed the quail nuclear marker. Similar results were obtained in quail/chick transplantation experiments. Hence, we suggest that the endothelium of the glomeruli is derived from outside vasculature rather than by conversion of cells in the nephrogenic mesenchyme.
肾小球内皮的起源一直未确定，尽管大多认为它像肾单位的其他部分一样源自后肾间充质。由于我们最近的观察结果不支持这一概念，因此利用小鼠/鹌鹑和鹌鹑/鸡种间移植对肾脏血管系统和肾小球内皮的发育进行了研究。将未分化的11日龄小鼠肾原基移植到鹌鹑尿囊膜上，并使其发育7 - 10天。检查发现，移植物血管化良好，肾小球和血管内皮均表达鹌鹑核标记物。在鹌鹑/鸡移植实验中也得到了类似结果。因此，我们认为肾小球内皮源自血管外组织，而非肾发生间充质中的细胞转化而来。
