Hill D J, Smart I J, Hosking C S
Clin Allergy. 1982 Jan;12(1):83-9. doi: 10.1111/j.1365-2222.1982.tb03129.x.
Lymphocyte stimulation, as determined by incorporation of thymidine, to rye grass extract in twenty-three children with bronchial reactivity to rye grass and to house dust mite, did not differ significantly from four children with reactivity to house dust mite alone, or from nine children with asthma but without a bronchial response to these allergens. Sixteen children underwent hyposensitization with rye grass extract or treatment with placebo. There was no consistent effect of hyposensitization on the lymphocyte stimulation indices to rye grass. A decrease in lymphocyte responsiveness occurred to rye grass and to house dust mite after the grass pollen season but was not statistically significant. Analysis of changes in lymphocyte responsiveness to both house dust mite and rye grass of the children most highly sensitized to rye allergen, showed that the lymphocyte responsiveness to rye grass fell during the pollen season (P less than 0.05) but this effect was not seen with house dust mite. The study suggests that a decrease in lymphocyte responsiveness to rye grass allergen in children with large amounts of anti-rye IgE antibodies is antigen specific and may be seen following seasonal exposure.
通过胸腺嘧啶核苷掺入法测定，23名对黑麦草和屋尘螨有支气管反应性的儿童对黑麦草提取物的淋巴细胞刺激，与4名仅对屋尘螨有反应性的儿童，或9名患有哮喘但对这些过敏原无支气管反应的儿童相比，无显著差异。16名儿童接受了黑麦草提取物脱敏治疗或安慰剂治疗。脱敏对黑麦草淋巴细胞刺激指数没有一致的影响。草花粉季节过后，对黑麦草和屋尘螨的淋巴细胞反应性有所下降，但无统计学意义。对黑麦过敏原高度敏感的儿童，分析其对屋尘螨和黑麦草的淋巴细胞反应性变化，结果显示，花粉季节期间对黑麦草的淋巴细胞反应性下降（P小于0.05），但对屋尘螨未见此效应。该研究表明，大量抗黑麦IgE抗体的儿童对黑麦草过敏原的淋巴细胞反应性降低具有抗原特异性，且可能在季节性暴露后出现。
