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一种冬眠哺乳动物在其年周期节律中大脑细胞膜脂质组成的变化。

Changes in lipid composition of the brain cellular membranes of an hibernating mammal during its circannual rhythm.

作者信息

Robert J, Montaudon D, Dubourg L, Rebel G, Miro J L, Canguilhem B

出版信息

Comp Biochem Physiol B. 1982;71(3):409-16. doi: 10.1016/0305-0491(82)90402-3.

DOI:10.1016/0305-0491(82)90402-3
PMID:7067403
Abstract

The lipid composition of whole brain hemispheres and subcellular fractions of European Hamsters (Cricetus cricetus) was investigated at four different periods of the year. 1. No difference was observed in winter between hibernating animals and active animals awake for 24 hr. 2. A slight increase of cholesterol/phospholipid molar ratio was observed in winter. 3. A slight increase of the ratio ethanolamine phosphoglycerides/choline phosphoglycerides was observed in summer and autumn. 4. Some changes in sugar moieties proportions of gangliosides were observed, with a tendency of increased polysialylation in winter. 5. An increase of docosahexaenoic acid was observed in summer, while a slight increase of linoleic acid and of the monounsaturated fatty acids was observed in winter. These changes were mainly exhibited in the synaptosomal fraction. All the changes observed were of very small magnitude and might not be sufficient for the maintenance of a fluid state of membranes during hibernation.

摘要

在一年中的四个不同时期,对欧洲仓鼠(黑线仓鼠)全脑半球和亚细胞组分的脂质组成进行了研究。1. 在冬季,冬眠动物与清醒24小时的活跃动物之间未观察到差异。2. 冬季观察到胆固醇/磷脂摩尔比略有增加。3. 夏季和秋季观察到乙醇胺磷酸甘油酯/胆碱磷酸甘油酯的比例略有增加。4. 观察到神经节苷脂糖部分比例的一些变化,冬季有多糖基化增加的趋势。5. 夏季观察到二十二碳六烯酸增加,而冬季观察到亚油酸和单不饱和脂肪酸略有增加。这些变化主要表现在突触体组分中。观察到的所有变化幅度都非常小,可能不足以在冬眠期间维持膜的流体状态。

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